The pathogenic microbial flora and its antibiotic susceptibility pattern in odontogenic infections.

Authors:
Paul Andrei Tent
Paul Andrei Tent
a Universitatea din Oradea Facultatea de Medicina si Farmacie
Raluca Iulia Juncar
Raluca Iulia Juncar
"Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca
Florin Onisor
Florin Onisor
Iuliu Hatieganu University of Medicine and Pharmacy
Simion Bran
Simion Bran
University of Medicine and Pharmacy Iuliu Hatieganu
Romania
Mihai Juncar
Mihai Juncar
"Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca
Romania

Drug Metab Rev 2019 Apr 18:1-16. Epub 2019 Apr 18.

a Dental Medicine , Universitatea din Oradea Facultatea de Medicina si Farmacie , Oradea , Romania.

Suppurative head and neck infections of odontogenic origin are the most frequent type of head and neck infections. According to the literature, 7-10% of all antibiotics are currently prescribed for their treatment. Since penicillin was invented, the overall antibiotic sensitivity and resistance pattern of the isolated pathogenic microflora has continuously changed. The response of microorganisms to antibiotics and the development of resistance to their action is a purely evolutive process characterized by genetic mutations, acquisition of genetic material or alteration of gene expression and metabolic adaptations. All this makes challenging and difficult the correct choice of empirical antibiotic treatment for head and neck space infections even today. The aim of this paper was to evaluate the literature and to evidence the most frequent locations of odontogenic head and neck infections, the dominant pathogenic microbial flora, the genetic mutations and metabolic changes necessary for bacteria in order to aquire antibiotic resistance and as well its susceptibility and resistance to common antibiotics. We also aimed to highlight the possible changes in bacterial resistance to antibiotics over time, and to assess whether or not there is a need for fundamental changes in the empirical antibiotic treatment of these infections and show which these would be.

Download full-text PDF

Source
http://dx.doi.org/10.1080/03602532.2019.1602630DOI Listing
April 2019
8 Reads

Publication Analysis

Top Keywords

head neck
16
neck infections
12
antibiotic treatment
8
pathogenic microbial
8
genetic mutations
8
microbial flora
8
empirical antibiotic
8
infections
6
resistance
5
antibiotic
5
treatment head
4
correct choice
4
choice empirical
4
infections today
4
paper evaluate
4
evaluate literature
4
literature evidence
4
aim paper
4
today aim
4
space infections
4

References

(Supplied by CrossRef)
Article in Med Oral
Arteagoitia M et al.
Med Oral 2016
Article in Pediatr Dent
American Academy of Pediatric Dentistry Council on Clinical Affairs et al.
Pediatr Dent 2013
Article in Am J Otolaryngol
Akst LM et al.
Am J Otolaryngol 2005
Article in Contemp Clin Dent
Bahl R et al.
Contemp Clin Dent 2014
Article in FEMS Microbiol Lett
Barcus VA et al.
FEMS Microbiol Lett 1995
Article in Med Oral Patol Oral Cir Bucal
Bascones Martínez A et al.
Med Oral Patol Oral Cir Bucal 2004
Article in J Adv Pharm Technol Res
Bhattacharya S et al.
J Adv Pharm Technol Res 2010

Similar Publications