Experimental Vertical Transmission of Chikungunya Virus by Brazilian and Florida Populations.

Authors:
Nildimar Alves Honorio
Nildimar Alves Honorio
Laboratório de Transmissores de Hematozoários
Bradley Eastmond
Bradley Eastmond
Florida Medical Entomology Laboratory
Vero Beach | United States
Barry W Alto
Barry W Alto
University of Florida
United States

Viruses 2019 Apr 17;11(4). Epub 2019 Apr 17.

University of Florida, IFAS, Department of Entomology and Nematology, Florida Medical Entomology Laboratory, Vero Beach, FL 32962, USA.

Chikungunya virus (CHIKV) is a vector-borne alphavirus transmitted by the bites of mosquitoes, specifically infected, female mosquitoes of the invasive species. In nature, CHIKV can be maintained by vertical transmission, a phenomenon that relates to the transfer of CHIKV from the infected parent to their offspring within the ovary or during oviposition. In the present study, we conducted laboratory experiments to determine vertical transmission with populations from Brazil and Florida. Parental females were orally infected with the emergent Asian genotype of CHIKV in the first gonotrophic cycle (infectious blood meal) and tested for vertical transmission following the second (non-infectious blood meal) gonotrophic cycle. CHIKV infection and CHIKV viral titer in parental females were significantly related to population origin, with Brazilian showing higher viral dissemination and viral titer than the Florida population. Experimental vertical transmission of CHIKV was documented in one pool of female and four pools of male from Brazil (minimum infection rate, MIR, of 0.76% and 2.86%, respectively, for females and males). For the Florida population of , only one pool of males was positive for CHIKV infection, with an MIR of 1.06%. Our results demonstrate that populations from Brazil and Florida show heterogeneous CHIKV dissemination and vertical transmission, which may contribute to the epidemiology of CHIKV and may be particularly relevant to virus survival during inter-epidemic periods.

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Source
https://www.mdpi.com/1999-4915/11/4/353
Publisher Site
http://dx.doi.org/10.3390/v11040353DOI Listing
April 2019
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Chikungunya virus disease
Jupp et al.

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