Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men.

Authors:
Helman Alfonso
Helman Alfonso
University of Western Australia
Australia
Jonathan Golledge
Jonathan Golledge
College of Medicine and Dentistry
Boston | United States
Paula Clancy
Paula Clancy
School of Medicine and Dentistry
Leon Flicker
Leon Flicker
University of Western Australia
Crawley | Australia
Jenny E Gunton
Jenny E Gunton
Westmead Hospital
Australia
Graeme J Hankey
Graeme J Hankey
School of Medicine and Pharmacology
New Haven | United States
Osvaldo P Almeida
Osvaldo P Almeida
School of Psychiatry & Clinical Neurosciences

Diabetes Metab Res Rev 2019 Apr 18:e3172. Epub 2019 Apr 18.

Medical School, University of Western Australia, Perth, Australia.

Aims: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.

Methods: Cross-sectional analysis of 4153 community-dwelling men aged 70 to 89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D, and glucose were assayed. Diabetes was ascertained from self-report, medications, and fasting glucose.

Results: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1 SD increase in ferritin, P = .006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1 SD, P < .001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, P = .83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR = 0.57, 95% CI = 0.43-0.75, P < .001). There was no interaction between ferritin and vitamin D on diabetes risk.

Conclusions: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions, which raise vitamin D concentrations, would reduce incidence of diabetes in this expanding demographic group.

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Source
http://dx.doi.org/10.1002/dmrr.3172DOI Listing
April 2019

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