Suspected resistance of Trypanosoma species to diminazene aceturate on a cattle farm in Nigeria.

Authors:
Paul Olalekan Odeniran
Paul Olalekan Odeniran
University of Ibadan
Ewan Thomas Macleod
Ewan Thomas Macleod
Edinburgh Medical School
Isaiah Oluwafemi Ademola
Isaiah Oluwafemi Ademola
University of Ibadan
Susan Christina Welburn
Susan Christina Welburn
University of Edinburgh
United Kingdom

Trop Anim Health Prod 2019 Apr 17. Epub 2019 Apr 17.

Division of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH8 9YL, UK.

African animal trypanosomiasis is a major cause of mortality and economic losses for the livestock industry in Nigeria. Chemotherapy has been the most reliable option for cattle herders, and the most commonly found drug on the market is diminazene aceturate. To ascertain the long-term efficacy of this compound, we sampled a cattle herd in Ogun State, Nigeria, 2 months after they were treated with diminazene aceturate. The ITS-PCR results revealed 19 positives for trypanosome DNA out of the 79 samples tested (24.1%, 95% CI 16.0-34.5). Seventeen out of the total 19 positives were Trypanosoma congolense (21.5%, 95% CI 13.9-31.8). Mixed infections were also observed. Therefore, the persistence of bovine trypanosomiasis at this Nigerian cattle farm despite treatment could be due to diminazene aceturate resistant trypanosomes being present in the herd.

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Source
http://link.springer.com/10.1007/s11250-019-01902-5
Publisher Site
http://dx.doi.org/10.1007/s11250-019-01902-5DOI Listing
April 2019
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