Potent antiviral activity of carbohydrate-specific algal and leguminous lectins from the Brazilian biodiversity.

Authors:
Leen Mathys
Leen Mathys
Rega Institute for Medical Research
Belgium
Sam Noppen
Sam Noppen
Rega Institute for Medical Research
Sandra Liekens
Sandra Liekens
Rega Institute for Medical Research
Belgium
Alexandre Holanda Sampaio
Alexandre Holanda Sampaio
Federal University of Ceará
Brazil
Celso S Nagano
Celso S Nagano
Cidade Universitária
Brazil

Medchemcomm 2019 Mar 14;10(3):390-398. Epub 2019 Jan 14.

Rega Institute for Medical Research , Department of Microbiology and Immunology , KU Leuven , 3000 Leuven , Belgium . Email:

Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: (ConBr), (ConM), (DLasiL) and (DSclerL), and algae (AML), (BSL), (HML), (MEL) and (SfL). They were exposed to a panel of 18 different viruses, including HIV and influenza viruses. Several lectins showed highly potent antiviral activity, often within the low nanomolar range. DSclerL and DLasiL exhibited EC values (effective concentration of lectin required to inhibit virus-induced cytopathicity by 50%) of 9 nM to 46 nM for HIV-1 and respiratory syncytial virus (RSV), respectively, DLasiL also inhibited feline corona virus at an EC of 5 nM, and DSclerL, ConBr and ConM showed remarkably low EC values ranging from 0.4 to 6 nM against influenza A virus strain H3N2 and influenza B virus. For HIV, evidence pointed to the blockage of entry of the virus into its target cells as the underlying mechanism of antiviral action of these lectins. Overall, the most promising lectins based on their EC values were DLasiL, DSclerL, ConBr, ConM, SfL and HML. These novel findings indicate that lectins from the Brazilian flora may provide novel antiviral compounds with therapeutic potential.

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http://dx.doi.org/10.1039/c8md00508gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430086PMC
March 2019
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