ACS Med Chem Lett 2019 Apr 26;10(4):639-643. Epub 2019 Feb 26.
Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain.
Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound , featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent.