Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease.

Authors:
Masashi Kono
Masashi Kono
Kinki University Faculty of Medicine
Toshiharu Sakurai
Toshiharu Sakurai
Kyoto University
Japan
Kazuki Okamoto
Kazuki Okamoto
St. Marianna University School of Medicine
Tomoyuki Nagai
Tomoyuki Nagai
Kinki University School of Medicine
Japan
Yoriaki Komeda
Yoriaki Komeda
Nara Medical University Hospital
Japan
Hiroshi Kashida
Hiroshi Kashida
Showa University Northern Yokohama Hospital
Japan
Kosuke Minaga, MD, PhD
Kosuke Minaga, MD, PhD
Kindai University Faculty of Medicine
Osaka-Sayama, OSAKA | Japan
Ken Kamata
Ken Kamata
Kinki University Faculty of Medicine

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.

Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. A 63-year-old man with a 7-year history of MDS was referred for examination of diarrhea, abdominal pain and fever. A blood examination revealed a marked elevation of C-reactive protein. Colonoscopy showed multiple ulcers in the terminal ileum. He was resistant to anti-TNF-α antibody and azacitidine. Subsequently, UST treatment reduced colonic IL-17 and IL-6 expression and the patient currently maintains a state of remission.

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http://dx.doi.org/10.2169/internalmedicine.2495-18DOI Listing
April 2019
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