Relationship between changes in resting-state spontaneous brain activity and cognitive impairment in patients with CADASIL.

Authors:
Jingjing Su
Jingjing Su
Shanghai Ninth People's Hospital
China
Mengxing Wang
Mengxing Wang
East China Normal University
China
Liang Wang
Liang Wang
College of Public Health
China
Xin Cheng
Xin Cheng
University of Toronto Scarborough
Canada
Fengchun Hua
Fengchun Hua
Huashan Hospital
China
Yuping Tang
Yuping Tang
Nanjing University of Chinese Medicine
China
Houguang Zhou
Houguang Zhou
Huashan Hospital
China

J Headache Pain 2019 Apr 17;20(1):36. Epub 2019 Apr 17.

Department of Neurology and Jiuyuan Municipal Stroke Center, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) mainly manifests with cognitive impairment. Cognitive deficits in patients with CADASIL are correlated with structural brain changes such as lacunar lesion burden, normalized brain volume, and anterior thalamic radiation lesions, but changes in resting-state functional brain activity in patients with CADASIL have not been reported.

Methods: This study used resting-state functional magnetic resonance imaging (fMRI) to measure the amplitude of low-frequency fluctuation (ALFF) in 22 patients with CADASIL and 44 healthy matched controls. A seed-based functional connectivity (FC) analysis was used to investigate whether the dysfunctional areas identified by ALFF analysis exhibited abnormal FC with other brain areas. Pearson's correlation analysis was used to detect correlations between the ALFF z-score of abnormal brain areas and clinical scores in patients with CADASIL.

Results: Patients with CADASIL exhibited significantly lower ALFF values in the right precuneus and cuneus (Pcu/CU) and higher ALFF values in the bilateral superior frontal gyrus (SFG) and left cerebellar anterior and posterior lobes compared with controls. Patients with CADASIL showed weaker FC between the areas with abnormal ALFF (using peaks in the left and right SFG and the right Pcu/CU) and other brain areas. Importantly, the ALFF z-scores for the left and right SFG were negatively associated with cognitive performance, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment scores (MoCA), respectively, whereas those of the right Pcu/CU were positively correlated with the MMSE score.

Conclusions: This preliminary study provides evidence for changes in ALFF of the right Pcu/CU, bilateral SFG and left cerebellar anterior and posterior lobes, and associations between ALFF values for abnormal brain areas and cognitive performance in patients with CADASIL. Therefore, spontaneous brain activity may be a novel imaging biomarker of cognitive impairment in this population.

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http://dx.doi.org/10.1186/s10194-019-0982-3DOI Listing
April 2019
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References

(Supplied by CrossRef)
Article in Lancet Neurol
H Chabriat et al.
Lancet Neurol 2009
Article in BMC Med
I Donato Di et al.
BMC Med 2017
Article in AJNR Am J Neuroradiol
S Singhal et al.
AJNR Am J Neuroradiol 2005
Article in Stroke
D Hervé et al.
Stroke 2009
Article in Stroke
M Dichgans et al.
Stroke 2002
Article in J Neuroimaging
M Mascalchi et al.
J Neuroimaging 2017
Article in Brain
M Duering et al.
Brain 2011
Article in J Clin Neurol
JS Lee et al.
J Clin Neurol 2011
Article in Stroke
MK Liem et al.
Stroke 2007

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