Intracellular Peptides in Cell Biology and Pharmacology.

Biomolecules 2019 Apr 16;9(4). Epub 2019 Apr 16.

Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo (USP), São Paulo 05508-000, Brazil.

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. However, only a few intracellular peptides have been pharmacologically characterized and their biological significance and mechanism of action remains elusive. Here, some historical and general aspects on intracellular peptides' biology and pharmacology are presented. Hemopressin and Pep19 are examples of intracellular peptides pharmacologically characterized as inverse agonists to cannabinoid type 1 G-protein coupled receptors (CB1R), and hemopressin fragment NFKF is shown herein to attenuate the symptoms of pilocarpine-induced epileptic seizures. Intracellular peptides EL28 (derived from proteasome 26S protease regulatory subunit 4; Rpt2), PepH (derived from Histone H2B type 1-H), and Pep5 (derived from G1/S-specific cyclin D2) are examples of peptides that function intracellularly. Intracellular peptides are suggested as biological functional molecules, and are also promising prototypes for new drug development.

Download full-text PDF

Source
https://www.mdpi.com/2218-273X/9/4/150
Publisher Site
http://dx.doi.org/10.3390/biom9040150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523763PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
April 2019
7 Reads

Publication Analysis

Top Keywords

intracellular peptides
32
peptides
9
intracellular
9
biology pharmacology
8
pharmacologically characterized
8
peptides pharmacologically
8
agonists cannabinoid
4
cannabinoid type
4
characterized inverse
4
pep19 examples
4
examples intracellular
4
type g-protein
4
inverse agonists
4
cb1r hemopressin
4
fragment nfkf
4
nfkf attenuate
4
attenuate symptoms
4
hemopressin fragment
4
hemopressin pep19
4
coupled receptors
4

References

(Supplied by CrossRef)
Synthesis of intracellular peptides in Torula utilis
McManus et al.
J. Biol. Chem. 1958

Similar Publications