Transient UV-vis absorption spectroscopic characterisation of 2'-methoxyacetophenone as a DNA photosensitiser.

Authors:
Miguel A Miranda
Miguel A Miranda
Universitat Politècnica de València
València | Spain

Spectrochim Acta A Mol Biomol Spectrosc 2019 Jul 6;218:191-195. Epub 2019 Apr 6.

Instituto Universitario Mixto de Tecnología Química, Universitat Politècnica de València (UPV-CSIC), Av. Los Naranjos s/n, 46022, Valencia, Spain. Electronic address:

2'-Methoxyacetophenone (2M) presents improved UVA absorption as compared with other acetophenone derivatives. On the basis of transient infrared spectroscopy it has been previously claimed that 2M is an interesting photosensitiser for cyclobutane pyrimidine dimers (CPDs) formation. In the present paper, a complete UV-Vis transient absorption spectroscopic characterisation of this compound is provided, including triplet-triplet spectra, triplet lifetimes and rate constants for quenching of 2M by a dimeric thymine derivative. Furthermore, generation of singlet oxygen has been proven by time-resolved near IR phosphorescence measurements. Overall, the obtained results confirm the potential of 2M as a DNA photosensitiser, not only for CPDs formation, but also for oxidative damage.

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http://dx.doi.org/10.1016/j.saa.2019.04.007DOI Listing
July 2019
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