Four new guaiane sesquiterpenoids from agarwood of Aquilaria filaria.

Authors:
Wen-Li Mei
Wen-Li Mei
Institute of Tropical Bioscience and Biotechnology
China
Hao Wang
Hao Wang
Zhongshan Hospital
Johns Creek | United States
Dr Li Yang, PhD
Dr Li Yang, PhD
Monash University
Clayton, Victoria | Australia
Wen-Hua Dong
Wen-Hua Dong
Institute of Tropical Bioscience and Biotechnology
China

Fitoterapia 2019 Jun 14;135:79-84. Epub 2019 Apr 14.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; Hainan Engineering Research Center of Agarwood, 571101 Haikou, PR China. Electronic address:

Six 8,12-epoxyguaiane sesquiterpenes (1-6), together with two known 2-(2-phenylethyl)chromone derivatives (7-8) were isolated from agarwood originating from Aquilaria filaria. Their structures were established by spectroscopic methods including IR, HRESIMS, 1D, and 2D NMR, and comparison with the published data. The absolute configuration of compound 1 was unambiguously determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum. All compounds were tested for their α-glucosidase inhibitory activity and cytotoxicity. Compound 5 showed significant α-glucosidase inhibitory activity with IC value of 253.2 ± 9.7 μM (Acarbose, 743. 4 ± 3.3 μM). Compounds 2-4 displayed weak cytotoxicity against K562 tumor cell lines.

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http://dx.doi.org/10.1016/j.fitote.2019.04.007DOI Listing
June 2019
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