Further terpenoids from Euphorbia tirucalli.

Authors:
Mehdi A Beniddir
Mehdi A Beniddir
Université Paris-Sud
France
Gregory Genta-Jouve
Gregory Genta-Jouve
University of Nice-Sophia Antipolis
France
Dinh-Phuoc Nguyen
Dinh-Phuoc Nguyen
Chulalongkorn University
Joel Boustie
Joel Boustie
University of Tuebingen
Germany

Fitoterapia 2019 Jun 14;135:44-51. Epub 2019 Apr 14.

BioCIS, Université Paris-Sud, CNRS, Université Paris-Saclay, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France. Electronic address:

The phytochemical investigation of Euphorbia tirucalli L. (Euphorbiaceae) yielded four new compounds, including a rare cadalene-type sesquiterpene (tirucadalenone), two tirucallane triterpenoids, euphorol L and euphorol M, with the latter being described as an epimeric mixture, and a euphane triterpene, namely, euphorol N, together with 7 known compounds. Their structures and absolute configurations were elucidated from analysis of 1D (1H, J-modulated C) and 2D NMR (HSQC, HMBC and NOESY), high-resolution mass spectrometry (HRESIMS), optical rotation, and GIAO NMR shift calculation followed by CP3 analysis, along with comparison with literature reports. All these compounds were tested for cytotoxicity against K562, MCF-7 and/or and HepG2 tumor cell lines. Only tirucadalenone displayed a mild cytotoxic activity.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S0367326X193044
Publisher Site
http://dx.doi.org/10.1016/j.fitote.2019.04.001DOI Listing
June 2019
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