Seed-Based Connectivity Analysis of Resting-State fMRI in Patients with Brain Tumors: A Feasibility Study.

Authors:
Hussam Metwali
Hussam Metwali
International Neuroscience Institute
Germany
Amir Samii
Amir Samii
International Neuroscience Institute

World Neurosurg 2019 Apr 14. Epub 2019 Apr 14.

Department of Neurosurgery, International Neuroscience Institute, Hannover, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany.

Objective: In this study, we present our experience using resting-state functional magnetic resonance imaging (rs-fMRI) in preoperative planning. We performed group analysis to demonstrate the effects of brain tumor on resting-state networks (RSNs).

Methods: Thirty patients with supratentorial gliomas were included in the study. Preoperative rs-fMRI and structural magnetic resonance imaging were performed in all cases. The rs-fMRI was preprocessed (realignment, slice time correction, coregistration to structural images, normalization, and smoothing). The structural images were segmented and normalized. Band filtering and denoising were applied to the functional images. Connectivity analysis was performed using seed-based connectivity analysis (SCA) at single subject level and group level. Correlation algorism has been used with r > 0.5.

Results: RSNs could be detected in all patients. They showed similarity to the results of the task-based fMRI, when task-based fMRI was feasible. Detection of the networks was also possible in patients with neurologic deficits, in whom task-based fMRI was not possible. We could use SCA in patients under anesthesia. High-level networks (default mode, salience, and dorsal attention networks) were detectable but showed a wide spectrum of spatial alterations and component disconnections.

Conclusions: rs-fMRI is a feasible method for extended brain mapping. Diverse RSNs could be detected in patients with brain tumors and could be applied in preoperative planning. SCA was a robust and direct approach for data analysis and could answer specific clinically relevant questions. However, further studies are needed to validate the technique and its clinical impact.

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Source
http://dx.doi.org/10.1016/j.wneu.2019.04.073DOI Listing
April 2019

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