Targeting Interleukin-6 Signaling in Clinic.

Authors:
Sujin Kang
Sujin Kang
Osaka University
Japan
Toshio Tanaka
Toshio Tanaka
Osaka University Graduate School of Medicine
Japan
Masashi Narazaki
Masashi Narazaki
Osaka University Graduate School of Medicine
Japan
Tadamitsu Kishimoto
Tadamitsu Kishimoto
Osaka University
Japan

Immunity 2019 Apr;50(4):1007-1023

Department of Immune Regulation, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita City, Osaka, Japan. Electronic address:

Interleukin-6 (IL-6) is a pleiotropic cytokine with roles in immunity, tissue regeneration, and metabolism. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive synthesis of IL-6 and dysregulation of IL-6 receptor signaling is involved in disease pathology. Therapeutic agents targeting the IL-6 axis are effective in rheumatoid arthritis, and applications are being extended to other settings of acute and chronic inflammation. Recent studies reveal that selective blockade of different modes of IL-6 receptor signaling has different outcomes on disease pathology, suggesting novel strategies for therapeutic intervention. However, some inflammatory diseases do not seem to respond to IL-6 blockade. Here, we review the current state of IL-6-targeting approaches in the clinic and discuss how to apply the growing understanding of the immunobiology of IL-6 to clinical decisions.

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Source
https://linkinghub.elsevier.com/retrieve/pii/S10747613193014
Publisher Site
http://dx.doi.org/10.1016/j.immuni.2019.03.026DOI Listing
April 2019
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