Parallel Processing of Sound Dynamics across Mouse Auditory Cortex via Spatially Patterned Thalamic Inputs and Distinct Areal Intracortical Circuits.

Authors:
Ji Liu
Ji Liu
Sichuan University
China
Matthew R Whiteway
Matthew R Whiteway
University of Maryland whit8022@umd.edu
Alireza Sheikhattar
Alireza Sheikhattar
University of Maryland
College Park | United States
Daniel A Butts
Daniel A Butts
College Park
United States
Behtash Babadi
Behtash Babadi
Massachusetts General Hospital
Patrick O Kanold
Patrick O Kanold
University of Maryland

Cell Rep 2019 Apr;27(3):872-885.e7

Department of Biology, University of Maryland, College Park, MD 20742, USA; Program in Neuroscience and Cognitive Science, University of Maryland, College Park, MD 20742, USA. Electronic address:

Natural sounds have rich spectrotemporal dynamics. Spectral information is spatially represented in the auditory cortex (ACX) via large-scale maps. However, the representation of temporal information, e.g., sound offset, is unclear. We perform multiscale imaging of neuronal and thalamic activity evoked by sound onset and offset in awake mouse ACX. ACX areas differed in onset responses (On-Rs) and offset responses (Off-Rs). Most excitatory L2/3 neurons show either On-Rs or Off-Rs, and ACX areas are characterized by differing fractions of On and Off-R neurons. Somatostatin and parvalbumin interneurons show distinct temporal dynamics, potentially amplifying Off-Rs. Functional network analysis shows that ACX areas contain distinct parallel onset and offset networks. Thalamic (MGB) terminals show either On-Rs or Off-Rs, indicating a thalamic origin of On and Off-R pathways. Thus, ACX areas spatially represent temporal features, and this representation is created by spatialĀ convergence and co-activation of distinct MGB inputs and is refined by specific intracortical connectivity.

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http://dx.doi.org/10.1016/j.celrep.2019.03.069DOI Listing
April 2019

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