Strength training and running elicit different neuroprotective outcomes in a β-amyloid peptide-mediated Alzheimer's disease model.

Authors:
Helen L Schimidt
Helen L Schimidt
Federal University of Pampa
Brazil
Alexandre Garcia
Alexandre Garcia
Australian Centre for Plant Functional Genomics and The University of Adelaide
Ivan Izquierdo
Ivan Izquierdo
Memory Center
Felipe P Carpes
Felipe P Carpes
Laboratory of Neuromechanics
Chennai | India

Physiol Behav 2019 Jul 14;206:206-212. Epub 2019 Apr 14.

Applied Neuromechanics Group, Federal University of Pampa, Uruguaiana, 97501-970, Brazil. Electronic address:

Aerobic exercise induces neuroprotection, but few studies investigated whether strength training has similar potential. Here we examine whether effects of strength training differ from those of running training concerning cognitive symptomatology, oxidative stress and cholinergic status in a model of AD-like cognitive impairment induced by intrahippocampal infusion of a mix of β-amyloid peptides (Aβ) in rats. Male Wistar rats were submitted to 8 weeks of running exercise (RunEx; 40 min sessions at 70% of indirect VO max, 3 times/week) or strength exercise (StrEx; 3 sessions/week, 12 repetitions in 8 sets, 2 sets with repetitions at 50%, 2 at 75%, 2 at 90% and 2 at 100% of the maximum load), followed by Aβ infusion in the dorsal hippocampus. Short-term (STM) and long-term (LTM) object recognition (OR) and social recognition (SR) memories were evaluated. Hippocampal oxidative status was determined by quantification of reactive oxygen species, lipid peroxidation by thiobarbituric acid reactive substance test, total antioxidant capacity by ferric reducing/antioxidant power, and acetylcholinesterase enzyme activity (AChE). Aβ infusion impaired STM and LTM and resulted in higher hippocampal oxidative damage and impaired AChE activity. StrEx results in better neuroprotection than RunEx by preventing deficits in OR and SR memories, prevents increases in lipid peroxidation, and decreases in AChE activity. RunEx elicits neuroprotection only for SR memory deficits, prevents increase in ROS and lipid peroxidation, and preserves the total antioxidant capacity. While RunEx effects are related to oxidative status, only StrEx shows potential to also influence the cholinergic system.

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http://dx.doi.org/10.1016/j.physbeh.2019.04.012DOI Listing
July 2019
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