Monoclonal antibodies point to Achilles' heel in picornavirus capsid.

Authors:
Mihnea Bostina
Mihnea Bostina
Harvard Medical School
United States

PLoS Biol 2019 Apr 17;17(4):e3000232. Epub 2019 Apr 17.

Department of Microbiology and Immunology and Otago Micro and Nano Imaging, University of Otago, Dunedin, New Zealand.

Picornaviruses are small, icosahedral, nonenveloped, positive-sense, single-stranded RNA viruses that form one of the largest and most important viral families. Numerous Picornaviridae members pose serious health or agricultural threats, causing diseases such as poliomyelitis, hepatitis A, or foot-and-mouth disease. The antigenic characterization of picornavirus capsids plays an important role in understanding the mechanism of viral neutralization and the conformational changes associated with genome release, and it can point to regions which can be targeted by small-molecule compounds to be developed as antiviral inhibitors. In a recent study, Cao and colleagues applied this strategy to hepatitis A virus (HAV) and used cryo-electron microscopy (cryo-EM) to characterize a well-conserved antigenic site recognized by several monoclonal antibodies. They further used computational approaches to identify a small-molecule drug with a strong inhibitory effect on cell attachment.

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.3000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490930PMC
April 2019
4 Reads

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 20, 2019, 5:59 pm EST
twitter
Twitter:
April 19, 2019, 9:27 pm EST
twitter
Twitter:
April 19, 2019, 12:50 am EST
twitter
Twitter:
April 19, 2019, 12:03 am EST
twitter
Twitter:
April 19, 2019, 12:01 am EST
twitter
Twitter:
April 18, 2019, 5:13 am EST
twitter
Twitter:
April 18, 2019, 5:09 am EST
twitter
Twitter:
April 18, 2019, 2:57 am EST
twitter
Twitter:
April 17, 2019, 6:14 pm EST
twitter
Twitter:
April 17, 2019, 3:53 pm EST
twitter
Twitter:
April 17, 2019, 3:10 pm EST
twitter
Twitter:
April 17, 2019, 3:01 pm EST
twitter
Twitter:
April 17, 2019, 2:45 pm EST

Publication Analysis

Top Keywords

monoclonal antibodies
8
microscopy cryo-em
4
characterization picornavirus
4
disease antigenic
4
picornavirus capsids
4
antigenic characterization
4
cryo-electron microscopy
4
understanding mechanism
4
role understanding
4
plays role
4
foot-and-mouth disease
4
capsids plays
4
hepatitis foot-and-mouth
4
threats causing
4
agricultural threats
4
antigenic site
4
health agricultural
4
study cao
4
causing diseases
4
mechanism viral
4

Altmetric Statistics

Similar Publications