Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission.

Authors:
Reyes A Murrieta
Reyes A Murrieta
College of Veterinary Medicine and Biomedical Sciences
Lincoln | United States
Andrea M Weiler
Andrea M Weiler
University of Wisconsin-Madison
United States
Matthew R Semler
Matthew R Semler
North Dakota State University
Fargo | United States

PLoS Negl Trop Dis 2019 Apr 17;13(4):e0007343. Epub 2019 Apr 17.

Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities; St. Paul, MN, United States of America.

Congenital Zika virus (ZIKV) infection was first linked to birth defects during the American outbreak in 2015/2016. It has been proposed that mutations unique to the Asian/American-genotype explain, at least in part, the ability of Asian/American ZIKV to cause congenital Zika syndrome (CZS). Recent studies identified mutations in ZIKV infecting humans that arose coincident with the outbreak in French Polynesia and were stably maintained during subsequent spread to the Americas. Here we show that African ZIKV can infect and harm fetuses and that the S139N substitution that has been associated with the American outbreak is not essential for fetal harm. Our findings, in a vertical transmission mouse model, suggest that ZIKV will remain a threat to pregnant women for the foreseeable future, including in Africa, Southeast Asia, and the Americas. Additional research is needed to better understand the risks associated with ZIKV infection during pregnancy, both in areas where the virus is newly endemic and where it has been circulating for decades.

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Source
http://dx.doi.org/10.1371/journal.pntd.0007343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488094PMC
April 2019

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