TIPE2 as a potential therapeutic target in chronic viral hepatitis.

Authors:
Jian Ji
Jian Ji
Zhejiang University
China
Yuan-Yuan Zhang
Yuan-Yuan Zhang
Jilin University
China
Yu-chen Fan
Yu-chen Fan
Qilu Hospital of Shandong University
China

Expert Opin Ther Targets 2019 Jun 22;23(6):485-493. Epub 2019 Apr 22.

c Department of Hepatology , Qilu Hospital of Shandong University , Jinan , China.

Introduction: Tumor necrosis factor-α-induced protein-8 like-2 (TIPE2) is a novel negative regulator of innate and adaptive immune responses by binding to caspase-8. The binding of TIPE2 and caspase-8 can inhibit the activity of activating protein-1(AP-1) and nuclear factor-κB (NF-κB), ultimately promoting Fas-induced apoptosis in immune cells. Therefore, TIPE2-caspase-8-NF-κB signaling might serve as a biomarker and a potential target for therapeutic intervention. Areas covered: This review summarizes the biological functions of TIPE2 in the regulation of immune homeostasis and the underlying mechanism by which TIPE2 is regulated in the human immune response. The molecular pathway of TIPE2-caspase-8 signaling in chronic infections of hepatitis B virus and hepatitis C virus is also explained. Expert opinion: Considering the essential role of TIPE2 in linking immunity and inflammation, this protein may be a promising therapeutic target in chronic viral hepatitis. However, studies are necessary to elucidate the molecular mechanism of TIPE2 in the immunogenesis of viral hepatitis and to develop potential interventions for breaking immune tolerance in chronic hepatitis B virus infection. Additional studies are required to understand how TIPE2 binds to caspase-8.

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Source
https://www.tandfonline.com/doi/full/10.1080/14728222.2019.1
Publisher Site
http://dx.doi.org/10.1080/14728222.2019.1608948DOI Listing
June 2019
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Mol Med Rep 2018

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