AJR Am J Roentgenol 2019 Apr 17:1-11. Epub 2019 Apr 17.
3 Department of Medical Imaging, University of Arizona, Tucson, AZ.
The purpose of this article is to provide a review of I-ioflupane SPECT in the evaluation of suspected parkinsonian syndromes (PSs). This collection of diseases presents frequent diagnostic challenges, even by movement disorder and dementia specialists. The I-ioflupane scan serves as an imaging biomarker of the status of presynaptic dopamine transporters (DATs) in the striatum. As a result of neuronal death, DATs are greatly reduced in patients with PS neurodegenerative disorders, whereas clinical mimics generally do not show striatal DAT loss. This provides a tremendous opportunity for I-ioflupane to aid in the accurate and timely diagnosis of these patients and optimize their management.