The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Authors:
Herbert B Schiller
Herbert B Schiller
Max Planck Institute of Biochemistry
Daniel T Montoro
Daniel T Montoro
Stanford University School of Medicine
United States
Lukas M Simon
Lukas M Simon
Baylor College of Medicine
Emma L Rawlins
Emma L Rawlins
Duke University Medical Center
United States
Kerstin B Meyer
Kerstin B Meyer
Cancer Research UK Cambridge Institute
United Kingdom
Maximilian Strunz
Maximilian Strunz
Comprehensive Pneumology Center
M√ľnchen | Germany
Wim Timens
Wim Timens
University of Groningen
Groningen | Netherlands

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments including the tissue resident structural and immune cells, the tissue matrix as well as the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body, and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach and the expected impact of a Human Lung Cell Atlas.

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Source
https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
Publisher Site
http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
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3.985 Impact Factor

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