Optical multiplexed bioassays improve biomedical diagnostics.

Authors:
Fan Zhang
Fan Zhang
School of Pharmacy
Madison | United States
Yong FAN
Yong FAN
The Third Affiliated Hospital of Guangzhou Medical College
China

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

CHINA.

Conventional analytical methods based on single detection to determine one disease marker are usually not sufficient and accurate because the progression of disease generally involves multiple chemicals and biomolecules. The drive for simultaneous analysis of multiple targets, which plays a key role in both basic biomedical research and clinical applications, demands the development of multiplexed bioassays with high-throughput. In this minireview, we systematically summarize the recent progress of optical multiplexed analytical techniques to improve biomedical diagnostics, in which fluorescence and surface enhanced Raman scattering (SERS) with distinctive optical features are chosen as the main readout signals. Taking advantage of the multiplexed strategies in the biomedical field, a selection of recent contributions from biosensing of multiple chemicals and multicolor cellular tracking to in vivo multiplexed bioimaging are highlighted. Finally, we frame the future outlook of challenges and opportunities of multiplexed bioanalysis.

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201901964DOI Listing
April 2019
1 Read

Publication Analysis

Top Keywords

biomedical diagnostics
8
multiple chemicals
8
multiplexed bioassays
8
improve biomedical
8
optical multiplexed
8
multiplexed
5
biomedical clinical
4
strategies biomedical
4
basic biomedical
4
cellular tracking
4
demands development
4
applications demands
4
distinctive optical
4
role basic
4
clinical applications
4
multicolor cellular
4
plays key
4
multiple targets
4
multiplexed strategies
4
analysis multiple
4

Similar Publications