Clinico-immunological spectrum of American tegumentary leishmaniasis and leprosy coinfection: A case series in Southeastern Brazil.

Authors:
Sebastian Vernal
Sebastian Vernal
Ribeirao Preto Medical School
Ribeirão Preto | Brazil
Ciro Martins Gomes
Ciro Martins Gomes
University Hospital of Brasilia
Brazil
Ana Maria Roselino
Ana Maria Roselino
Ribeirão Preto Medical School
Brazil

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180172. Epub 2019 Apr 11.

Divisão de Dermatologia, Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Introduction: American tegumentary leishmaniasis (ATL) and leprosy share common areas of prevalence, but reports of coinfection are scarce.

Methods: We report a series of 9 ATL-leprosy cases and discuss the association. An integrative diagram to analyze the clinico-immunological features of coinfection with both diseases.

Results: Nine patients with leishmaniasis (5 cutaneous, 3 mucocutaneous, 1 disseminated case) exhibited concurrent infection with distinct clinical forms of leprosy. Our diagram-based analysis evidenced a divergent clinico-immunological spectrum for each disease in 8 out of 9 cases.

Conclusions: The spectrum of ATL-leprosy comorbidity suggests that the host has a specific immune response against each pathogen.

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http://dx.doi.org/10.1590/0037-8682-0172-2018DOI Listing
April 2019
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