Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms.

Authors:
Rogier W Sanders
Rogier W Sanders
Academic Medical Center
Amsterdam-Zuidoost | Netherlands

Curr Opin HIV AIDS 2019 Apr 30. Epub 2019 Apr 30.

Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Purpose Of Review: We will discuss recent advances in the development of nanoparticle vaccines presenting HIV-1 envelope trimer vaccines and the immunological mechanisms by which they act.

Recent Findings: The multivalent presentation of Env trimers on nanoparticles is a promising strategy to increase Env immunogenicity. Recent studies have shed light on how Env nanoparticles increase lymph node trafficking and germinal center formation by using the lectin-mediated complement pathway and enhancing the interaction with naïve B cells. Meanwhile, research on different nanoparticle platforms has resulted in improved designs, such as liposomes with improved stability, and the emergence of novel platforms such as protein nanoparticles that self-assemble in vitro. Immmunogenicity studies with these nanoparticles delineate the advantages and expose the limitations of the different nanoparticle platforms.

Summary: It is becoming increasingly clear that HIV-1 vaccine research might benefit greatly from using nanoparticles presenting Env trimers, particularly during the priming stage of immunization. Among the different nanoparticles that are being pursued, in vitro-assembling nanoparticles allow for greater control of Env quality making them a promising nanoparticle platform.

Download full-text PDF

Source
http://dx.doi.org/10.1097/COH.0000000000000549DOI Listing
April 2019
10 Reads

Publication Analysis

Top Keywords

hiv-1 envelope
8
env trimers
8
nanoparticle platforms
8
nanoparticles
7
env
5
nanoparticle
5
stability emergence
4
designs liposomes
4
improved stability
4
liposomes improved
4
novel platforms
4
vitro immmunogenicity
4
immmunogenicity studies
4
self-assemble vitro
4
nanoparticles self-assemble
4
platforms protein
4
protein nanoparticles
4
emergence novel
4
cells nanoparticle
4
germinal center
4

Similar Publications