Comparison of the LIAISON®XL and ARCHITECT IgG, IgM, and IgG avidity assays for the diagnosis of Toxoplasma, cytomegalovirus, and rubella virus infections.

Authors:
Francesca Genco
Francesca Genco
University of Pavia
Italy
Antonella Sarasini
Antonella Sarasini
Servizio di Virologia IRCCS Policlinico San Matteo and University of Pavia
Italy
Maurizio Parea
Maurizio Parea
Fondazione IRCCS Policlinico San Matteo
Martina Prestia
Martina Prestia
" University of Pavia
Italy
Luigia Scudeller
Luigia Scudeller
Clinical Epidemiology Unit
Boston | United States

New Microbiol 2019 Apr 17;41(2). Epub 2019 Apr 17.

SC Microbiologia e Virologia Fondazione IRCCS Policlinico San Matteo Pavia, Italy.

This study compared the performance of the LIAISON®XL system of immunoglobulin (Ig) G and IgM immunoassays for the diagnosis of Toxoplasma gondii, cytomegalovirus (CMV), and rubella virus infections with that of the ARCHITECT system. Patient serum samples, previously screened and clinically diagnosed with T. gondii, CMV or rubella, were used to compare LIAISON®XL and ARCHITECT IgG and IgM immunoassays. LIAISON®XL Toxo and CMV IgG avidity assays were also compared with equivalent ARCHITECT assays and reference methods. Overall agreement between the LIAISON®XL and ARCHITECT assays was 99% and 92% for the Toxo IgG and IgM assays, respectively, 98% and 96% for the CMV IgG and IgM assays, respectively, and 93% and 98% for the rubella virus IgG and IgM assays, respectively. LIAISON®XL IgG Toxo and CMV avidity assays showed high concordance with the VIDAS® Toxo IgG avidity assay and an in-house CMV avidity assay (reference methods), and faster IgG avidity maturation in a larger number of samples collected months after the primary infection compared with equivalent ARCHITECT assays. LIAISON®XL assays for detection of anti-T. gondii, CMV and rubella virus IgG and IgM are at least equal to the competitor assays on the ARCHITECT platform.

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April 2019
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