Infection as a Predictor of Low Aerobic Capacity in Ugandan Children.

Authors:
Courtney Smith
Courtney Smith
Lankenau Institute for Medical Research
Mr Moses Adriko, MSc
Mr Moses Adriko, MSc
Vector Borne and Neglected Tropical Disease Division, Ministry of Health
Mr
NTDs
Kampala, East Africa | Uganda
Moses Arinaitwe
Moses Arinaitwe
Liverpool School of Tropical Medicine
United Kingdom
Aaron Atuhaire
Aaron Atuhaire
Liverpool School of Tropical Medicine
United Kingdom
Edridah Muheki Tukahebwa
Edridah Muheki Tukahebwa
Vector Control Division

Am J Trop Med Hyg 2019 Jun;100(6):1498-1506

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset ( = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg min (interquartile range: 42.9-48.0 mL kg min). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg min, = 0.031). The prevalence of stunting, wasting, egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg min, < 0.001). Multivariable-adjusted analysis revealed a strong negative association between egg patent infection and VO2max at low altitude (beta coefficient: -3.96, 95% CI: -6.56 to -137, = 0.004). This is the first study to document a negative association between infection and aerobic capacity at low altitudes using the 20mSRT.

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Source
http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0922
Publisher Site
http://dx.doi.org/10.4269/ajtmh.18-0922DOI Listing
June 2019
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