Liver Microphysiological Systems for Predicting and Evaluating Drug Effects.

Authors:
Xinning Yang
Xinning Yang
State University of New York
United States
Vikram Patel
Vikram Patel
London School of Hygiene and Tropical Medicine
United Kingdom
Rajnikanth Madabushi
Rajnikanth Madabushi
Office of Clinical Pharmacology
United States
David G Strauss
David G Strauss
Department of Clinical Physiology
Sweden

Clin Pharmacol Ther 2019 Apr 16. Epub 2019 Apr 16.

U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science.

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse effects. Microphysiological systems (MPS), also known as organs-on-a-chip, are a class of microfluidic platforms that recreate properties of tissue microenvironments. Among different properties, the liver microenvironment is three-dimensional, fluid flows around its cells, and different cell types regulate its function. Liver MPS aim to recreate these properties and enable drug testing and measurement of functional endpoints. Tests with these systems have demonstrated their potential for predicting clinical drug effects. Properties of liver MPS that improve the physiology of cell culture are reviewed, specifically focusing on the importance of recreating a physiological microenvironment to evaluate and model drug effects. Advances in modeling hepatic function by leveraging MPS are addressed, noting the need for standardization in the use, quality control, and interpretation of data from these systems. This article is protected by copyright. All rights reserved.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1458
Publisher Site
http://dx.doi.org/10.1002/cpt.1458DOI Listing
April 2019
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