Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection.

Authors:
Nicholas T Funderburg
Nicholas T Funderburg
Case Western Reserve University
United States

Curr HIV/AIDS Rep 2019 Apr 16. Epub 2019 Apr 16.

School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University College of Medicine, 453 W. 10th Ave. 535A Atwell Hall, Columbus, OH, 43210, USA.

Purpose Of Review: Human immunodeficiency virus (HIV) infection and its treatment with antiretroviral therapy (ART) are associated with lipid abnormalities that may enhance cardiovascular disease risk (CVD).

Recent Findings: Chronic inflammation persists in HIV+ individuals, and complex relationships exist among lipids and inflammation, as immune activation may be both a cause and a consequence of lipid abnormalities in HIV infection. Advances in mass spectrometry-based techniques now allow for detailed measurements of individual lipid species; improved lipid measurement might better evaluate CVD risk compared with the prognostic value of traditional assessments. Lipidomic analyses have begun to characterize dynamic changes in lipid composition during HIV infection and following treatment with ART, and further investigation may identify novel lipid biomarkers predictive of adverse outcomes. Developing strategies to improve management of comorbidities in the HIV+ population is important, and statin therapy and lifestyle modifications, including diet and exercise, may help to improve lipid levels and mitigate CVD risk.

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http://link.springer.com/10.1007/s11904-019-00442-9
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http://dx.doi.org/10.1007/s11904-019-00442-9DOI Listing
April 2019
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