Recent advances in carbohydrate-based cancer vaccines.

Authors:
Huan-Rong Lan
Huan-Rong Lan
Shaoxing People's Hospital (Shaoxing Hospital
Xiao-yi Chen
Xiao-yi Chen
Medical College of Chinese People's Armed Police Forces
China
Shi-Bing Wang
Shi-Bing Wang
National Taiwan University Hospital
Taiwan
Yan Lin
Yan Lin
Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization
China
Xiao-zhou Mou
Xiao-zhou Mou
China; People's Hospital of Tongling
China

Biotechnol Lett 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014, Zhejiang, People's Republic of China.

Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal "healthy" cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Antibodies generated against the carbohydrate antigens partake in the inactivation of carbohydrate-decorated cancer cells, by slowing down tumor cell growth and inducing cancer cell apoptosis. Novel synthetic strategies for carbohydrate antigens have led to several synthetic cancer vaccine candidates. In the present review, we describe the latest progress in carbohydrate-based cancer vaccines and their clinical evaluation in various cancers.

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http://dx.doi.org/10.1007/s10529-019-02675-5DOI Listing
April 2019
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