Advances in surgical applications of growth factors for wound healing.

Authors:
Sho Yamakawa
Sho Yamakawa
National Hospital Organization Nagasaki Medical Center
Kenji Hayashida
Kenji Hayashida
Nagasaki University School of Medicine
Japan

Burns Trauma 2019 5;7:10. Epub 2019 Apr 5.

Division of Plastic and Reconstructive Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501 Japan.

Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation , allowing for external modulation of the healing process. Perioperative drug delivery systems can enhance the biological activity of these growth factors, which have a very short half-life after topical administration. Although the basic mechanisms of these growth factors are well understood, most have yet to demonstrate a significant impact in animal studies or small-sized clinical trials. In this review, we emphasized currently approved growth factor therapies, including a sustained release system for growth factors, emerging therapies, and future research possibilities combined with surgical procedures. Approaches seeking to understand wound healing at a systemic level are currently ongoing. However, further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.

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Source
http://dx.doi.org/10.1186/s41038-019-0148-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450003PMC
April 2019

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