Standard laboratory housing for mice restricts their ability to segregate space into clean and dirty areas.

Authors:
Becca Franks
Becca Franks
Columbia University
United States
Tina Jorgensen
Tina Jorgensen
University of Copenhagen
Daniel M Weary
Daniel M Weary
University of British Columbia
Toronto | Canada

Sci Rep 2019 Apr 16;9(1):6179. Epub 2019 Apr 16.

Animal Welfare Program, University of British Columbia, 2357 Main Mall, Vancouver, BC, V6T 1Z4, Canada.

Laboratory mice (Mus musculus) are typically housed in simple cages consisting of one open space. These standard cages may thwart mouse ability to segregate resting areas from areas where they eliminate, a behaviour that is prevalent across the animal kingdom. No scientific work has directly tested whether mice engage in such segregation behaviour, or whether the ability to do so may have welfare consequences. Here we show that mice, whether housed in standard cages or a complex housing system consisting of three interconnected standard cages, kept nesting and elimination sites highly segregated, with nest and urine co-occurring in the same location only 2% of the time. However, mice in the complex system established these clean and dirty sites in separate cages instead of separate locations within one cage, and carried bedding materials (cellulose pellets) from their nesting cages to their latrine cage. Moreover, mice in the complex system displayed more behaviours associated with positive welfare and were less disturbed by weekly husbandry procedures. We conclude that mice find waste products aversive, and that housing mice in a way that facilitates spatial segregation provides a simple way of allowing the expression of natural behaviours and improving welfare.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42512-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467917PMC
April 2019

Publication Analysis

Top Keywords

standard cages
12
mice complex
8
ability segregate
8
housing mice
8
clean dirty
8
complex system
8
mice
8
cages
6
housed standard
4
mice housed
4
welfare consequences
4
cages complex
4
consequences mice
4
cages latrine
4
housing system
4
system consisting
4
cage mice
4
consisting three
4
latrine cage
4
complex housing
4

Similar Publications