Bactericidal effects and accelerated wound healing using TbO nanoparticles with intrinsic oxidase-like activity.

Authors:
Chen Li
Chen Li
Catalytic Hydrogenation Research Center
China
Yurong Sun
Yurong Sun
Clinicopathological Diagnosis Center
Xiaoping Li
Xiaoping Li
National University of Singapore
Singapore
Sanhong Fan
Sanhong Fan
College of Life Sciences
China
Yimin Liu
Yimin Liu
Department of Clinical Laboratory
China
Xiumei Jiang
Xiumei Jiang
National Taiwan University
Taiwan
Mary D Boudreau
Mary D Boudreau
College Park
United States
Yue Pan
Yue Pan
Institute of Medical Biology
China

J Nanobiotechnology 2019 Apr 16;17(1):54. Epub 2019 Apr 16.

Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA.

Background: Nanomaterials that exhibit intrinsic enzyme-like characteristics have shown great promise as potential antibacterial agents. However, many of them exhibit inefficient antibacterial activity and biosafety problems that limit their usefulness. The development of new nanomaterials with good biocompatibility and rapid bactericidal effects is therefore highly desirable. Here, we show a new type of terbium oxide nanoparticles (TbO NPs) with intrinsic oxidase-like activity for in vitro and in vivo antibacterial application.

Results: We find that TbO NPs can quickly oxidize a series of organic substrates in the absence of hydrogen peroxide. The oxidase-like capacity of TbO NPs allows these NPs to consume antioxidant biomolecules and generate reactive oxygen species to disable bacteria in vitro. Moreover, the in vivo experiments showed that TbO NPs are efficacious in wound-healing and are protective of normal tissues.

Conclusions: Our results reveal that TbO NPs have intrinsic oxidase-like activity and show effective antibacterial ability both in vitro and in vivo. These findings demonstrate that TbO NPs are effective antibacterial agents and may have a potential application in wound healing.

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Source
http://dx.doi.org/10.1186/s12951-019-0487-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466657PMC

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April 2019
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