The Polyphenol-Rich Extract from an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection.

Authors:
Elodie Clain
Elodie Clain
Université de La Réunion
Juliano G Haddad
Juliano G Haddad
University of Lille
Andrea C Koishi
Andrea C Koishi
Molecular Virology Laboratory
Cork | Ireland
Laura Sinigaglia
Laura Sinigaglia
Pasteur Institute
Paris | France
Walid Rachidi
Walid Rachidi
UCD School of Biomolecular and Biomedical Science

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La Réunion, France.

The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from , an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the extract interfered with the attachment of the viral particles to the host cells. Importantly, the extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.

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Source
https://www.mdpi.com/1422-0067/20/8/1860
Publisher Site
http://dx.doi.org/10.3390/ijms20081860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515236PMC
April 2019
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