Gastric Cancer in Northern Canadian Populations: A Focus on Cardia and Non-Cardia Subsites.

Authors:
Andre Corriveau
Andre Corriveau
University of Alberta
Canada
Brendan Hanley
Brendan Hanley
University of British Columbia
Canada
Yan Yuan
Yan Yuan
University of California
United States
Karen J Goodman
Karen J Goodman
University of Alberta

Cancers (Basel) 2019 Apr 15;11(4). Epub 2019 Apr 15.

The CANHelp Working Group, University of Alberta, Edmonton, AB T6G 2E1, Canada.

In northern Canada where there is a high prevalence of infection, there is a paucity of information on gastric cancer by the topographical subsites cardia (CGC) and non-cardia (NCGC). Here we describe the incidence of CGC and NCGC, separately, among northern Canadian populations. We used data from the Cancer Incidence in Five Continents Volumes X (CI5X) and XI (CI5XI) to obtain CGC and NCGC incidence for Canada and for Yukon (YT), a northern Canadian territory. Using these data with those provided by the Government of the Northwest Territories (NT), we estimated standardized incidence ratios comparing northern populations to Canada as a whole. We also estimated age-standardized incidence rates to permit comparisons across populations globally. NT and YT populations were disproportionately impacted by gastric cancer, particularly NCGC. This was especially true for Indigenous populations: NCGC incidence rates among NT Indigenous men were 2.7 times the rates among all men in Canada, while rates among NT Indigenous women were 3.1 times the rates among all women in Canada. Similarly, age-standardized rates of NCGC among Indigenous NT residents were comparable to global regions where there is a high burden of NCGC. This study has, for the first time, quantified the incidence of CGC and NCGC for the NT and YT, providing new insights into the burden of these cancers among northern Canadian populations.

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Source
http://dx.doi.org/10.3390/cancers11040534DOI Listing
April 2019
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