Genes associated with Parkinson's disease respond to increasing polychlorinated biphenyl levels in the blood of healthy females.

Authors:
Sacha Bohler
Sacha Bohler
Hasselt University
Belgium
Julian Krauskopf
Julian Krauskopf
Maastricht University
Stephan Gebel
Stephan Gebel
Philip Morris Research Laboratories GmbH
Domenico Palli
Domenico Palli
Cancer Research and Prevention Institute (ISPO)
United Kingdom
Panu Rantakokko
Panu Rantakokko
National Institute for Health and Welfare
Finland
Hannu Kiviranta
Hannu Kiviranta
National Public Health Institute
Finland
Soterios A Kyrtopoulos
Soterios A Kyrtopoulos
Institute of Biological Research and Biotechnology
Greece

Environ Pollut 2019 Jul 8;250:107-117. Epub 2019 Apr 8.

Department of Toxicogenomics, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands, 6229, ER Maastricht, the Netherlands.

Polychlorinated biphenyls (PCBs) are a class of widespread environmental pollutants, commonly found in human blood, that have been suggested to be linked to the occurrence of sporadic Parkinson's disease (PD). It has been reported that some non-coplanar PCBs accumulate in the brains of female PD patients. To improve our understanding of the association between PCB exposure and PD risk we have applied whole transcriptome gene expression analysis in blood cells from 594 PCB-exposed subjects (369 female, 225 male). Interestingly, we observe that in females, blood levels of non-coplanar PCBs appear to be associated with expression levels of PD-specific genes. However, no such association was detected in males. Among the 131 PD-specific genes affected, 39 have been shown to display similar changes in expression levels in the substantia nigra of deceased PD patients. Especially among the down-regulated genes, transcripts of genes involved in neurotransmitter vesicle-related functions were predominant.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envpol.2019.04.005DOI Listing
July 2019
1 Read

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 14, 2019, 7:42 am EST

Publication Analysis

Top Keywords

parkinson's disease
8
non-coplanar pcbs
8
pd-specific genes
8
expression levels
8
genes
5
risk applied
4
changes expression
4
exposure risk
4
pcb exposure
4
transcriptome gene
4
expression analysis
4
gene expression
4
levels substantia
4
display changes
4
applied transcriptome
4
improve understanding
4
levels pd-specific
4
nigra deceased
4
pcbs accumulate
4
deceased patients
4

Similar Publications