The impact of attention deficit hyperactivity disorder in obsessive-compulsive disorder subjects.

Authors:
Matheus Santos
Matheus Santos
Federal University of São Paulo
Albina R Torres
Albina R Torres
Botucatu Medical School
Euripedes C Miguel
Euripedes C Miguel
University of São Paulo Medical School
Michael H Bloch
Michael H Bloch
Yale University School of Medicine
United States
James F Leckman
James F Leckman
Child Study Center

Depress Anxiety 2019 Jun 16;36(6):533-542. Epub 2019 Apr 16.

Child and Adolescent Psychiatry Unit (UPIA), Department of Psychiatry, Federal University of São Paulo, São Paulo, Brazil.

Background: Recent findings suggest an association between attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Thus, we evaluated the clinical associated features of ADHD in a large sample of adult OCD patients.

Methods: A cross-sectional study including 955 adult patients with OCD from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (C-TOC). Clinical characteristics in adult OCD patients with and without comorbid ADHD were compared using Fisher's exact test, t-tests or Mann-Whitney tests. Bivariate analyses were followed by logistic regression analysis to identify clinical characteristics independently associated with ADHD comorbidity.

Results: The lifetime prevalence of ADHD in adult OCD patients was 13.7%. The current results indicate that OCD + ADHD patients were more severe, had an earlier onset of the obsessive-compulsive symptoms, a higher history of rheumatic fever, with higher frequencies of sensory phenomena and comorbidity with Tourette syndrome. They also had an increased risk for academic impairment and suicide attempts.

Conclusion: Adult OCD patients with ADHD present some specific clinical features and may represent a special subgroup of adult OCD. Future studies should focus on the development of interventions more tailored to the phenotype of this subgroup of patients.

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Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22898
Publisher Site
http://dx.doi.org/10.1002/da.22898DOI Listing

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June 2019
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