Oxidation reduction potential: a new biomarker of male infertility.

Authors:
Ana D Martins
Ana D Martins
University of Beira Interior
Dr. Ashok Agarwal, PhD
Dr. Ashok Agarwal, PhD
Center for Reproductive Medicine, Cleveland Clinic
Professor, Lerner College of Medicine; Director, Andrology Center and Center for Reproductive Medicine
Andrology, Male Infertility, Reproductive Health and Biology
Cleveland, Ohio | United States

Panminerva Med 2019 Jun;61(2):108-117

American Center for Reproductive Medicine, Department of Urology, Cleveland Clinic, Cleveland, OH, USA -

Oxidative stress is considered a major etiology for male infertility, more specifically idiopathic infertility. The causes of seminal oxidative stress can be intrinsic, such as varicocele or due to the presence of active leukocytes and immature germ cells. Reported external causes are smoking, alcohol or exposure to environmental toxins. Traditional methods to determine the seminal oxidative stress do not evaluate this status directly, but rather measure its components or intermediate products indirectly, instead. The major disadvantages of the traditional methods are related with time and cost as these methods are extremely time consuming and require expensive equipment, consumables and highly skilled laboratory personnel. To overcome these drawbacks, the MiOXSYS® system, a method which directly measures the oxidation-reduction potential (ORP), was developed. The evaluation of the ORP using MiOXSYS® is cost-effective, easy and quick. However, this newly introduced method to evaluate the oxidative status of semen still requires validation in different andrology laboratory settings across the world.

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Source
https://www.minervamedica.it/index2.php?show=R41Y2019N02A010
Publisher Site
http://dx.doi.org/10.23736/S0031-0808.18.03529-2DOI Listing
June 2019
8 Reads
2.276 Impact Factor

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References

(Supplied by CrossRef)
Fertility and infertility: definition and epidemiology
Vander Borght M et al.
Clin Biochem 2018

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