Molecular interplay of autophagy and endocytosis in human health and diseases.

Authors:
Kewal K Mahapatra
Kewal K Mahapatra
National Institute of Technology Rourkela
Debasna P Panigrahi
Debasna P Panigrahi
National Institute of Technology Rourkela
Rourkela | India
Prakash P Praharaj
Prakash P Praharaj
National Institute of Technology Rourkela
Research Fellow
Cancer Biologist
Rourkela, Odisha | India
Srimanta Patra
Srimanta Patra
National Institute of Technology Rourkela
Bishnu P Behera
Bishnu P Behera
National Institute of Technology Rourkela
Sujit K Bhutia
Sujit K Bhutia
National Institute of Technology
Thanesar | India

Biol Rev Camb Philos Soc 2019 Apr 15. Epub 2019 Apr 15.

Department of Life Science, National Institute of Technology Rourkela, Sundergarh, Odisha 769008, India.

Autophagy, an evolutionarily conserved process for maintaining the physio-metabolic equilibrium of cells, shares many common effector proteins with endocytosis. For example, tethering proteins involved in fusion like Ras-like GTPases (Rabs), soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs), lysosomal-associated membrane protein (LAMP), and endosomal sorting complex required for transport (ESCRT) have a dual role in endocytosis and autophagy, and the trafficking routes of these processes converge at lysosomes. These common effectors indicate an association between budding and fusion of membrane-bound vesicles that may have a substantial role in autophagic lysosome reformation, by sensing cellular stress levels. Therefore, autophagy-endocytosis crosstalk may be significant and implicates a novel endocytic regulatory pathway of autophagy. Moreover, endocytosis has a pivotal role in the intake of signalling molecules, which in turn activates cascades that can result in pathophysiological conditions. This review discusses the basic mechanisms of this crosstalk and its implications in order to identify potential novel therapeutic targets for various human diseases.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/brv.12515
Publisher Site
http://dx.doi.org/10.1111/brv.12515DOI Listing
April 2019
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References

(Supplied by CrossRef)
Regulation of autophagy by the Rab GTPase network
Ao X. et al.
Cell Death and Differentiation 2014
Autophagy: cancer's friend or foe?
Bhutia S. K. et al.
Advances in Cancer Research 2013
Prelysosomal compartments in the unconventional secretion of amyloidogenic seeds
Borland H. et al.
International Journal of Molecular Sciences 2017
Phosphorylated Presenilin 1 decreases beta‐amyloid by facilitating autophagosome‐lysosome fusion
Bustos V. et al.
Proceedings of the National Academy of Sciences of the United States of America 2017
SNARE‐mediated membrane fusion
Chen Y. A. et al.
Nature Reviews Molecular Cell Biology 2001

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