Comparing the incidence of ventricular arrhythmias during epicardial ablation in swine versus canine models.

Authors:
Guido Caluori
Guido Caluori
St. Anne's University Hospital
Adam Wojtaszczyk
Adam Wojtaszczyk
Center for Cardiovascular Research and Development
Omar Yasin
Omar Yasin
University of Michigan School of Medicine
Martin Pesl
Martin Pesl
Masaryk University
Czech Republic
Jiri Wolf
Jiri Wolf
Masaryk University Brno
Czech Republic
Silvie Belaskova
Silvie Belaskova
International Clinical Research Center
Murfreesboro | United States
Michal Crha
Michal Crha
University of Veterinary and Pharmaceutical Sciences
Czech Republic
Alan Sugrue
Alan Sugrue
Galway University Hospital
Ireland

Pacing Clin Electrophysiol 2019 Apr 15. Epub 2019 Apr 15.

International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.

Background: Choosing the appropriate animal model for development of novel technologies requires an understanding of anatomy and physiology of these different models. There are little data about the characteristics of different animal models for the study of technologies used for epicardial ablation. We aimed to compare the incidence of ventricular arrhythmias during epicardial radiofrequency ablation between swine and canine models using novel epicardial ablation catheters.

Methods: We conducted a retrospective study using data obtained from epicardial ablation experiments performed on swine (Sus Scrofa) and canine (Canis familiaris) models. We compared the incidence of ventricular arrhythmias during ablation between swine and canine using multivariate regression analysis. Six swine and six canine animals underwent successful epicardial radiofrequency ablation. A total of 103 ablation applications were recorded.

Results: Ventricular arrhythmias requiring cardioversion occurred in 13.11% of radiofrequency ablation applications in swine and 9.75% in canine (relative risk: 117.6%, 95% confidence interval [CI]: 83.97-164.69, animal-based odds ratio [OR]: .55, 95% CI: .23-61.33; P = .184). When adjusting for application position, duration of ablation and power, the odds of developing potentially lethal ventricular arrhythmia in swine increased significantly compared to canine (OR: 3.60, 95% CI: 1.35-9.55; P = .010).

Conclusions: The swine myocardium is more susceptible to developing ventricular arrhythmias compared to canine model during epicardial ablation. This issue should be carefully considered in future studies.

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http://dx.doi.org/10.1111/pace.13698DOI Listing
April 2019
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(Supplied by CrossRef)
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Arrhythm Electrophysiol Rev 2012
American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology
Houser SR et al.
Circ Res 2012
Animal models of cardiovascular diseases
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J Biomed Biotechnol 2011

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