Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Authors:
Ferran Barbe
Ferran Barbe
Hospital Arnau de Vilanova
Angels Betriu
Angels Betriu
Hospital Universitari Arnau de Vilanova
Spain
Anna Michela Gaeta
Anna Michela Gaeta
Arnau de Vilanova and Santa Maria Universitary Hospital
Reinald Pamplona
Reinald Pamplona
University of Lleida
Spain

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

Aims: Patients with type 2 diabetes have been considered a susceptible group for pulmonary dysfunction. Our aim was to assess pulmonary function on the prediabetes stage.

Methods: Pulmonary function was assessed in 4,459 non-diabetic subjects, aged between 45 and 70 years, without cardiovascular disease or chronic pulmonary obstructive disease from the ongoing study ILERVAS. A "restrictive spirometric pattern", an "abnormal FEV1" and an "obstructive ventilatory defect" were assessed. Prediabetes was defined by glycosylated hemoglobin (HbA1c) between 5.7 and 6.4% according to the American Diabetes Association criteria.

Results: Population was composed of 52.1% women, aged 57 [53;63] years, a BMI of 28.6 [25.8;31.8] kg/m, and with a prevalence of prediabetes of 29.9% (n = 1392). Subjects with prediabetes had lower forced vital capacity (FVC: 93 [82;105] vs. 96 [84;106], p < 0.001) and lower forced expired volume in the first second (FEV1: 94 [82;107] vs. 96 [84;108], p = 0.011), as well as a higher percentage of the restrictive spirometric pattern (16.5% vs. 13.6%, p = 0.015) and FEV1 < 80% (20.3% vs. 17.2%, p = 0.017) compared to non-prediabetes group. In the prediabetes group, HbA1c was negatively correlated with both pulmonary parameters (FVC: r = - 0.113, p < 0.001; FEV1: r = - 0.079, p = 0.003). The multivariable logistic regression model in the whole population showed that there was a significant and independent association between HbA1c with both restrictive spirometric pattern [OR = 1.42 (1.10-1.83), p = 0.008] and FEV1 < 80% [OR = 1.50 (1.19-1.90), p = 0.001].

Conclusions: The deleterious effect of type 2 diabetes on pulmonary function appears to be initiated in prediabetes, and it is related to metabolic control. TRIAL REGISTRATION CLINICALTRIALS.GOV: NCT03228459.

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019
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References

(Supplied by CrossRef)
Article in Endocr Rev
A Lecube et al.
Endocr Rev 2017
Article in Chest
B Borst van den et al.
Chest 2010
Article in Diabet Med
OL Klein et al.
Diabet Med 2010
Article in Diabetes Res Clin Pract
TM Davis et al.
Diabetes Res Clin Pract 2000
Article in Am J Respir Crit Care Med
RE Walter et al.
Am J Respir Crit Care Med 2003
Article in Diabetes Care
HC Yeh et al.
Diabetes Care 2008
Article in Arkh Patol
IM Kodolova et al.
Arkh Patol 1982
Article in Diabetes Care
WW Chance et al.
Diabetes Care 2008
Article in Diabetes Metab
E Sánchez et al.
Diabetes Metab 2018
Article in Biochim Biophys Acta
MJ Bellmunt et al.
Biochim Biophys Acta 1995
Article in Eur Respir J
P Lange et al.
Eur Respir J 1990

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