A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015.

Authors:
Sang Hyoung Park
Sang Hyoung Park
University of Ulsan College of Medicine
South Korea
Kyoung Hoon Rhee
Kyoung Hoon Rhee
Konkuk University School of Medicine
Young-Ho Kim
Young-Ho Kim
South Korea
Sung Noh Hong
Sung Noh Hong
Sungkyunkwan University School of Medicine
South Korea
Kyung Ho Kim
Kyung Ho Kim
National Medical Center
Washington | United States
Seung In Seo
Seung In Seo
Hallym University College of Medicine
Jae Myung Cha
Jae Myung Cha
Kyung Hee University College of Medicine
South Korea

J Crohns Colitis 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background And Aims: Although the incidence of inflammatory bowel disease (IBD) is increasing in Asia, data on long-term epidemiologic trends are limited. We performed a 30-year longitudinal study to investigate temporal trends in the epidemiology of Crohn's disease (CD) and ulcerative colitis (UC) in Seoul, Korea.

Methods: This population-based study included 1431 IBD patients (418 CD, 1013 UC) diagnosed between 1986 and 2015 in the Songpa-Kangdong district of Seoul, Korea. Temporal trends in incidence, prevalence, and disease phenotype at diagnosis were analyzed.

Results: The adjusted mean annual incidence rates of CD and UC per 100,000 inhabitants increased from 0.06 (95% confidence interval [CI], 0.05-0.07) and 0.29 (95% CI, 0.27-0.31), respectively, in 1986-1990 to 2.44 (95% CI, 2.38-2.50) and 5.82 (95% CI, 5.73-5.92), respectively, in 2011-2015. Average annual percentage change in IBD incidence was 12.3% in 1986-1995, 12.3% in 1996-2005, and 3.3% in 2006-2015. The male-to-female ratio of the adjusted incidence rate was 3.3:1 for CD and 1.2:1 for UC. Perianal fistula/abscess was present in 43.3% of patients before or at CD diagnosis. At diagnosis, 54.3% of UC patients presented only with proctitis. The adjusted prevalence rate in 2015 was 31.59/100,000 (95% CI, 31.10-32.07) for CD and 76.66/100,000 (95% CI, 75.91-77.42) for UC.

Conclusions: The incidence and prevalence of IBD in Korea have continued to increase over the past three decades. Korean patients have distinct demographic and phenotypic characteristics including a male predominance and high frequency of perianal fistula/abscess in CD and high proportion of proctitis in UC.

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http://dx.doi.org/10.1093/ecco-jcc/jjz081DOI Listing

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April 2019
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