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J Card Fail 2021 Apr 16. Epub 2021 Apr 16.

University of Washington, Department of Medicine, RR-512, Health Sciences Building, Box 356420, 1959 NE Pacific Street, Seattle, WA 98195-6420, United States of America; University of Washington, Department of Epidemiology, UW Box #351619, Seattle, WA 98195, United States of America. Electronic address:

Background: Angiopoietin-1 and 2 (Ang1, Ang2) are important mediators of angiogenesis. Angiopoietin levels are perturbed in cardiovascular disease, but it is unclear whether angiopoietin signaling is causative, an adaptive response, or merely epiphenomenon of disease activity.

Methods And Results: In a cohort free of cardiovascular disease at baseline (MESA), relationships between angiopoietins, cardiac morphology, and subsequent incidence of heart failure or cardiovascular death were evaluated. Read More

ACS Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

Department of Cell Biology and Molecular Genetics, University of Maryland at College Park, College Park, Maryland 20742, United States.

is a Gram-negative opportunistic pathogen that is frequently found in the airways of cystic fibrosis (CF) patients due to the dehydrated mucus that collapses the underlying cilia and prevents mucociliary clearance. During this life-long chronic infection, cell accumulates mutations that lead to inactivation of the gene that results in the constitutive expression of operon and the production of alginate exopolysaccharide. The viscous alginate polysaccharide further occludes the airways of CF patients and serves as a protective matrix to shield from host immune cells and antibiotic therapy. Read More

Front Pediatr 2021 1;9:663228. Epub 2021 Apr 1.

Division of Pediatric Pulmonology, Allergy and Endocrinology, Departement of Pediatrics and Adolescent Medicine, Comprehensive Center of Pediatrics, Medical University of Vienna, Vienna, Austria.

Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Read More

Front Pediatr 2021 31;9:640184. Epub 2021 Mar 31.

Children's Health Ireland and Tallaght University Hospital, Dublin, Ireland.

Cystic Fibrosis (CF) lung damage begins early in life. Lung function decline is associated with pulmonary infections, neutrophil infiltration and inflammation. In CF, neutrophils have an altered phenotype. Read More

Front Cell Infect Microbiol 2021 1;11:656984. Epub 2021 Apr 1.

Laboratory of Basic and Applied Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil.

Biogenic silver nanoparticles (bio-AgNPs) are increasingly recognized as an antibiofilm and antivirulence strategy against , a bacterium that causes chronic infections in immunocompromised and cystic fibrosis patients. This study aimed to investigate the effects of subinhibitory concentrations of bio-AgNPs on motility and biofilm formation in . Bio-AgNPs were synthesized reduction of ionic silver catalyzed by cell-free culture filtrate from . Read More