Report on the 2018 Cancer, Autoimmunity, and Immunology Conference.

Authors:
Colleen S Curran
Colleen S Curran
University of Wisconsin
Madison | United States
Howard A Young
Howard A Young
National Cancer Institute
United States
Katarzyna Bourcier
Katarzyna Bourcier
Brigham and Women's Hospital
United States
Elad Sharon
Elad Sharon
National Cancer Institute
United States

J Immunol 2019 May 15;202(10):2823-2828. Epub 2019 Apr 15.

Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892

With the increased use of cancer immunotherapy, a number of immune-related adverse events (irAEs) are being identified. These irAEs can be compared with known autoimmune disorders in similar tissues, with important similarities and differences. Understanding the etiology of irAEs may bring to light concepts applicable to immune responses in cancer, autoimmunity, and infectious disease. This immunobiology is especially relevant to cancer patients with preexisting allogeneic transplants or autoimmune disease who are undergoing cancer immunotherapy. To address these facets of cancer immunotherapy, academic leaders from these various disciplines discussed current irAE basic and clinical research, irAE diagnosis and management, and the need for biomarkers and algorithms to identify individuals at risk for irAEs at a conference jointly sponsored by the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, MD, on March 22-23, 2018. Mechanisms and models to characterize irAEs, standardize protocols, store biospecimens, and capture and analyze irAE data were also reviewed during the inaugural Cancer, Autoimmunity, and Immunology Conference. This summary highlights cancer immunotherapy-induced irAEs, the challenges ahead, and the opportunities for greater understanding of autoimmune conditions.

Download full-text PDF

Source
http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1900264
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1900264DOI Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
May 2019
6 Reads

Publication Analysis

Top Keywords

cancer autoimmunity
12
cancer immunotherapy
12
cancer
9
national institute
8
immunology conference
8
autoimmunity immunology
8
iraes
6
iraes conference
4
jointly sponsored
4
conference jointly
4
risk iraes
4
algorithms identify
4
identify individuals
4
individuals risk
4
institute national
4
infectious diseases
4
diseases national
4
allergy infectious
4
institute allergy
4
national cancer
4

Similar Publications