Cost-effectiveness of faecal calprotectin used in primary care in the diagnosis of inflammatory bowel disease.

Authors:
Mr. Wei Zhang, PhD
Mr. Wei Zhang, PhD
University of Minnesota Twin Cities
Minneapolis, Minnesota | United States
Mallory Chavannes
Mallory Chavannes
Jewish General Hospital
Tima Mohammadi
Tima Mohammadi
University of British Columbia
Canada
Greg Rosenfeld
Greg Rosenfeld
University of British Columbia
Canada

BMJ Open 2019 Apr 14;9(4):e027043. Epub 2019 Apr 14.

Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, Canada.

Objective: Inflammatory bowel disease (IBD) is a chronic, autoimmune, gastrointestinal disorder. Canada has one of the highest prevalence and incidence rates of IBD in the world. Diagnosis is challenging due to the similarity of symptoms to functional gastrointestinal disorders. Faecalcalprotectin (FC) is a biomarker for active mucosal inflammation and has proven effective in the diagnosis of IBD. Our study objective was to assess the cost-effectiveness of adding an FC test compared with standard practice (blood test) in primary care among adult patients presenting with gastrointestinal symptoms.

Design: We constructed a decision analytic tree with a 1-year time horizon. The cut-off level of 100 µg/g was used for FC testing. Probabilistic analyses were conducted for the base case and all scenarios.

Setting: Canadian health sector perspective.

Population: A hypothetical cohort of adult patients presenting with gastrointestinal symptoms in the primary care setting.

Interventions: FC test compared with blood test.

Main Outcome Measures: Costs, quality-adjusted life years (QALYs), incremental cost-effectiveness ratio (ICER) of FC test expressed as cost per QALY gained compared with blood test and time to IBD diagnosis.

Results: FC testing is expected to cost more ($C295.1 vs $C273.9) than standard practice but yield little higher QALY (0.751vs0.750). The ICER of FC test was $C20 323 per QALY. Probabilistic analysis demonstrated that at a willingness-to-pay threshold of $C50 000 per QALY, there was 81.3% probability of FC test being cost-effective. The use of FC test in primary care reduced the time to IBD diagnosis by 40.0 days (95% CI 16.3 to 65.3 days), compared with blood testing alone.

Conclusions: Based on this analysis of short-term outcomes, screening adult patients in primary care using FC test at a cut-off level of 100 µg/g is expected to be cost-effective in Canada.

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500206PMC
April 2019

Publication Analysis

Top Keywords

primary care
20
adult patients
12
compared blood
12
test
9
time ibd
8
patients presenting
8
presenting gastrointestinal
8
test primary
8
icer test
8
test compared
8
bowel disease
8
ibd diagnosis
8
standard practice
8
blood test
8
cut-off level
8
level 100 µg/g
8
inflammatory bowel
8
primary
5
ibd
5
care
5

Similar Publications