A case report of Guillain Barré syndrome revealing underlying infective endocarditis due to Cardiobacterium hominis.

Authors:
Caroline Jacquet
Caroline Jacquet
CHRU de Nancy
Nancy | France
Corentine Alauzet
Corentine Alauzet
Nancy Université
France
Thierry May
Thierry May
University Hospital of Nancy
France
Christine Selton-Suty
Christine Selton-Suty
University Hospital of Nancy
France
Bruno Hoen
Bruno Hoen
Université des Antilles et de la Guyane
United States

Medicine (Baltimore) 2019 Apr;98(15):e15014

Service de Cardiologie Médicale, CHU de Nancy Hôpitaux de Brabois, Vandœuvre-lès-Nancy, France.

Rationale: Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy presumed to result from an infection-triggered autoimmune reaction.

Patient Concerns: This paper describes a 53-year-old man admitted to hospital for deterioration of his general condition.

Diagnosis: He developed GBS, confirmed by lumbar puncture and electromyogram, which recovered after intravenous immunoglobulins. A grade 2 aortic regurgitation was detected by transthoracic echocardiography upon diagnosis of GBS, but in the absence of fever, no further investigations were conducted. A few weeks later, the patient presented with fever and infective endocarditis (IE) was diagnosed after the identification of vegetation on the aortic valve with transesophageal echocardiography. The etiologic agent was identified as Cardiobacterium hominis based on 3 positive blood cultures and DNA detection in valvular material.

Interventions: IE was cured with a 6-week course of antibiotics and aortic valve replacement.

Outcomes: The patient completely recovered from Guillain-Baré syndrome and IE.

Lessons: This case of GBS associated with C hominis endocarditis, emphasizes the importance of blood cultures and transesophageal echocardiography for the detection of IE and highlights the insidious nature of C hominis endocarditis which is often diagnosed late.

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Source
http://dx.doi.org/10.1097/MD.0000000000015014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485866PMC

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April 2019
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