CD28 CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.

Authors:
Alejandra Pera
Alejandra Pera
Hospital Ramón y Cajal
Spain
Kevin A Davies
Kevin A Davies
Hammersmith Hospital
United Kingdom
Florian Kern
Florian Kern
Brighton and Sussex Medical School
United Kingdom

F1000Res 2019 25;8. Epub 2019 Mar 25.

Department of Clinical and Experimental medicine, Brighton and Sussex Medical School, Brighton, Sussex, BN1 9PX, UK.

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28 ). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other chronic inflammatory diseases and their numbers appeared to be linked to disease severity. However, we recently demonstrated that the common herpes virus, cytomegalovirus (CMV), not ageing, is the major driver of this subset of cytotoxic T cells. In this review, we discuss how CMV might potentiate and exacerbate autoimmune disease through the expansion of CD28 CD4 T cells.

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.17119.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436193PMC
March 2019
1 Read

Publication Analysis

Top Keywords

cd4 cells
12
autoimmune disease
8
cd28 cd4
8
erythematosus multiple
4
lupus erythematosus
4
systemic lupus
4
multiple sclerosis
4
chronic inflammatory
4
numbers appeared
4
diseases numbers
4
inflammatory diseases
4
arthritis systemic
4
sclerosis chronic
4
cd28
4
cytotoxic cd4
4
highly cytotoxic
4
cd28 highly
4
cd28 cd28
4
cells isolated
4
isolated disease-affected
4

Similar Publications