The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway.

Authors:
Liang Yang
Liang Yang
Nanyang Technological University
Singapore
Bing Xu
Bing Xu
Brandeis University
Waltham | United States
Zhi Dai
Zhi Dai
Fudan University
China
Yong Wang
Yong Wang
Guilin Medical University
Guilin Shi | China
Qifan Yang
Qifan Yang
Key Lab of Combined Multi-Organ Transplantation
China
Nuomin Li
Nuomin Li
School of Life Science
Thiruvananthapuram | India

Evid Based Complement Alternat Med 2019 10;2019:5421528. Epub 2019 Mar 10.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress plays an important role in neuronal diseases. As a traditional Chinese medicine, Zhengtian Pill (ZTP) was reported to have the ability to reduce the blood viscosity of migraine model rats, with increased beta-endorphin, serotonin, adrenaline, and dopamine in brain tissue. Moreover ZTP can effectively accelerate blood circulation and attenuate blood coagulation. However, the molecular mechanisms of ZPT are still unclear. Through the behavioral test we found that ZTP can significantly improve depression-like behavior induced by LPS when rat was treated with ZTP (L 0.17 g/kg, M 0.34 g/kg, and H 0.7 g/kg) intraperitoneal injection once a day for 30 consecutive days. And ZTP can resist oxidative stress (>72 h) for a longer time. And ZTP can promote the levels of ATP and SOD and reduce the levels of ROS and MDA in the brain. At the same time, ZTP can have antioxidant stress through increasing the expression level of Nrf2/HO-1/P38. These results show that ZTP may be a potential antioxidant stress drug for variety of diseases associated with oxidative stress injury.

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Source
https://www.hindawi.com/journals/ecam/2019/5421528/
Publisher Site
http://dx.doi.org/10.1155/2019/5421528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431467PMC
March 2019
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References

(Supplied by CrossRef)
Article in The Journal of The Japan Medical Association
The Journal of The Japan Medical Association 2000

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