IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.

Clin Mol Allergy 2019 2;17. Epub 2019 Apr 2.

Department of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.

Background: There is a strong and consistent association between IgE sensitization and allergy, wheeze, eczema and food hypersensitivity. These conditions are also found in non-sensitized humans, and sensitization is found among individuals without allergy-related diseases. The aim of this study was to analyse the sensitization profile in a representative sample of the population, and to relate patterns of allergens and allergen components to allergic symptoms.

Methods: A population of 195 adolescents took part in this clinical study, which included a self-reported questionnaire and in vitro IgE testing.

Results: Sensitization to airborne allergens was significantly more common than sensitization to food allergens, 43% vs. 14%, respectively. IgE response was significantly higher in airborne allergens among adolescents with rhinitis (p < 0.001) and eczema (p < 0.01). Among 53 children with allergic symptoms according to the questionnaire, 60% were sensitized. Sensitization to food allergens was found among those with rhinitis, but only to PR-10 proteins. None of the participants had IgE to seed storage proteins.

Conclusion: The adolescents in this study, taken from a normal Swedish population, were mainly sensitized to grass pollen and rarely to specific food allergens. The major grass pollen allergen Phl p 1 was the main sensitizer, followed by Cyn d 1 and Phl p 2. Sixty-one percent reporting any allergic symptom were sensitized, and the allergen components associated with wheeze and rhinoconjunctivitis were Fel d 4, Der f 2 and Can f 5.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12948-019-0110-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444864PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
April 2019
5 Reads

Publication Analysis

Top Keywords

ige sensitization
8
airborne allergens
8
sensitization
5
allergen components
4
components allergic
4
allergens allergen
4
allergic symptomsmethods
4
population 195
4
adolescents clinical
4
195 adolescents
4
patterns allergens
4
symptomsmethods population
4
relate patterns
4
analyse sensitization
4
study analyse
4
aim study
4
diseases aim
4
sensitization profile
4
ige
4
clinical study
4

References

(Supplied by CrossRef)
Article in Pediatr Allergy Immunol
SP Nissen et al.
Pediatr Allergy Immunol 2013
Article in Allergy
N Ballardini et al.
Allergy 2012
Article in J Wheeze
T Sterner et al.
J Wheeze 2018
Article in Allergy
T Stemeseder et al.
Allergy 2017
Article in Allergy
N Ballardini et al.
Allergy 2016
Article in Pediatr Allergy Immunol
ES Christiansen et al.
Pediatr Allergy Immunol 2016
Article in Allergy
J Garcia-Aymerich et al.
Allergy 2015
Article in Int Arch Allergy Immunol
E Scala et al.
Int Arch Allergy Immunol 2017
Article in Allergy
G Roberts et al.
Allergy 2013
Article in Lancet Respir Med
M Pinart et al.
Lancet Respir Med 2014
Article in J Allergy Clin Immunol
L Hatzler et al.
J Allergy Clin Immunol 2012

Similar Publications