Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature.

Authors:
Robert G Nicholas
Robert G Nicholas
University of New Mexico Hospital
Duncan A Meiklejohn
Duncan A Meiklejohn
*Stanford University Medical Center
Stanford | United States

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Physical examination demonstrated a 2.5 cm ulcerative lesion of the anterior right oral tongue. An initial biopsy was consistent with moderately to poorly differentiated squamous cell carcinoma. Imaging included a positron emission tomography (PET)/computed tomography (CT) scan that demonstrated the right tongue lesion as well as hypermetabolic right level II adenopathy. The patient underwent surgical excision of the right tongue, upper aerodigestive tract endoscopy, and a bilateral supraomohyoid neck dissection. The tongue defect was closed primarily.

Results: Final pathology of the surgical specimen demonstrated myoepithelial cell carcinoma. All of the margins were free of tumor and no cervical lymph nodes showed metastasis. Immunohistochemistry demonstrated myoepithelial differentiation. The tumor did not show EWSR1 gene rearrangement on genetic testing, suggesting salivary gland origin. Multidisciplinary tumor board evaluation recommended no adjuvant therapy. The patient recovered well after surgery and nearly a year later is without evidence of recurrent or residual disease.

Conclusions: We present the first reported case of myoepithelial cell carcinoma with primary origin in the oral tongue and review the available literature on this unusual tumor. We discuss the clinical, pathological, and immunohistochemical features and treatment of myoepithelial cell carcinoma.

Download full-text PDF

Source
http://dx.doi.org/10.1177/1179554919838254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448097PMC
April 2019
8 Reads

Article Mentions


Provided by Crossref Event Data
twitter
Twitter:
April 5, 2019, 6:30 pm EST

Publication Analysis

Top Keywords

cell carcinoma
24
myoepithelial cell
20
oral tongue
12
demonstrated myoepithelial
8
review literature
8
salivary gland
8
gland origin
8
tongue
7
carcinoma
6
myoepithelial
6
cell
5
neck dissection
4
bilateral supraomohyoid
4
supraomohyoid neck
4
tract endoscopy
4
upper aerodigestive
4
dissection tongue
4
tongue upper
4
aerodigestive tract
4
endoscopy bilateral
4

References

(Supplied by CrossRef)
Article in Arch Pathol Lab Med
Sheldon W. et al.
Arch Pathol Lab Med 1943
Article in Arch Pathol
Bauer W et al.
Arch Pathol 1945
Article in Arch Pathol
Stromeyer FW et al.
Arch Pathol 1975
Article in Cancer
Seifert G et al.
Cancer 1992

Similar Publications