Biophysical Measurements and Ultrasonographic Findings in Chronic Dermatitis in Comparison with Uninvolved Skin.

Indian J Dermatol 2019 Mar-Apr;64(2):90-96

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nowadays noninvasive techniques are performed to evaluate the biophysical properties of skin .

Aims: The aim of this study was to evaluate the biophysical and ultrasonographic properties of skin in chronic contact or atopic dermatitis to provide better insight into pathogenesis, diagnosis, and treatment response.

Materials And Methods: The stratum corneum hydration, transepidermal water loss (TEWL), pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, and R5), the thickness and echo-density of epidermis, dermis, and subepidermal low-echogenic band (SLEB) were measured on lesional, perilesional, and symmetrical skin of 22 chronic dermatitis patients. The average of perilesional and symmetrical skin values (control) was compared with lesional values.

Results: Stratum corneum hydration (<0.001), friction (=0.02), sebum (=0.01), and R0 (<0.001) were significantly lower in lesion, TEWL (=0.03), pH (=0.001), erythema (=0.004), and temperature (=0.04) were significantly higher in lesion. The thickness of epidermis (=0.002), dermis (=0.034), and SLEB (<0.001) were significantly higher in lesion; and the echo-density of dermis (<0.001) and SLEB (<0.001) was significantly lower in lesion.

Conclusion: Chronic contact and atopic dermatitis are characterized by certain changes in biophysical and biomechanical properties of the skin. The evaluation of these parameters might be useful in the early diagnosis and assessment of treatment response.

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijd.IJD_464_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440184PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
April 2019
8 Reads

Publication Analysis

Top Keywords

stratum corneum
8
properties skin
8
perilesional symmetrical
8
evaluate biophysical
8
skin chronic
8
symmetrical skin
8
chronic dermatitis
8
corneum hydration
8
skin
5
subepidermal low-echogenic
4
contact atopic
4
chronic contact
4
measured lesional
4
dermis subepidermal
4
insight pathogenesis
4
atopic dermatitis
4
better insight
4
low-echogenic band
4
band sleb
4
pathogenesis diagnosis
4

Similar Publications